Travoprost-d7

Travoprost-d7 (Fluprostenol isopropyl ester-d7) is deuterium labeled Travoprost. Travoprost (Fluprostenol isopropyl ester), an isopropyl ester proagent, is a high affinity, selective FP prostaglandin full receptor agonist. Travoprost has the ocular hypotensive efficacy and has the potential for glaucoma and ocular hypertension[1].

Fluprostenol isopropyl ester-d7; AL6221-d7; Flu-Ipr-d7

12352005

Isotope-Labeled Compounds; Prostaglandin Receptor

GPCR/G Protein; Others

Metabolism-protein/nucleotide metabolism

Endocrinology; Cardiovascular Disease

O=C(CCC/C=C\C[C@@H]1[C@H]([C@@H](C[C@@H]1O)O)/C=C/[C@H](COC2=CC=CC(C(F)(F)F)=C2)O)OC([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]

C26H28D7F3O6

507.59

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]M R Hellberg, et al. Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist. J Ocul Pharmacol Ther. 2001 Oct;17 (5) :421-32.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0584S2/

Isotope-Labeled Compounds

No Development Reported