Traxoprodil (Standaard)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Traxoprodil (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC50 of 10 nM.
134234-12-1
12352005
IGluR
Membrane Transporter/Ion Channel; Neuronal Signaling
Neurological Disease
OC1(C2=CC=CC=C2)CCN([C@@H](C)[C@@H](O)C3=CC=C(O)C=C3)CC1
C20H25NO3
327.42
[1]Chenard BL, et al. (1S,2S) -1- (4-hydroxyphenyl) -2- (4-hydroxy-4-phenylpiperidino) -1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses. J Med Chem. 1995 Aug 4;38 (16) :3138-45.|[2]Poleszak E, et al. Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice. Metab Brain Dis. 2016 Aug;31 (4) :803-14.|[3]Naspolini AP, et al. Traxoprodil decreases pentylenetetrazol-induced seizures. Epilepsy Res. 2012 Jun;100 (1-2) :12-9.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W018061R/
Reference Standards
Beschrijving
Traxoprodil (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC50 of 10 nM.
Specificaties
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