TREX1 Antilichaam

TREX1 Antibody: Trex1 is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.

11277

Q9NSU2

NP_057465

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

TREX1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1306 - Human Spleen Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (92%)

TREX1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TREX1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

TREX1 antibody will not cross-react with the related protein TREX2. At least three isoforms of TREX1 are known to exist; this antibody will recognize all three isoforms.

TREX1

Cat. No. 10-901 - Human Spleen Tissue Slide

Three prime repair exonuclease 1

Homo sapiens

Mazur DJ and Perrino FW. Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3→5 exonucleases. J. Biol. Chem. 1999; 274:19655-60.

Cortez D, Guntuku S, Qin J, et. al. ATR and ATRIP: partners in checkpoint signaling. Science 2001 294:1713-6

Stetson DB, Ko JS, Heidmann T, et al. Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 2008 134:587-98.

Mazur DJ and Perrino FW. Structure and expression of the TREX1 and TREX2 3'→5' exonuclease genes. J. Biol. Chem. 2001; 276:14718-27.

TREX1 Antibody: CRV, AGS1, DRN3, HERNS, Three prime repair exonuclease 1, DNase III

ELISA, WB, IHC-P, IF

7705353

Liquid