TRIM5 alfa Antilichaam

TRIM5 alpha Antibody: TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region. TRIM5 has six alternately spliced isoforms, the longest of which is the alpha variant which also contains a carboxy-terminal B30.2 (SPRY) domain. Expression of TRIM5α variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1, albeit at differing efficiencies. All TRIM5α variants could inhibit at least two different retroviruses, but not from those viruses isolated from the same species, suggesting that TRIM5α acts as a natural barrier to cross-species retrovirus transmission.

574288

Q0PF16

ABG67967

Human

Unconjugated

Primary Antibodies

Infectious Disease

TRIM5 alpha Antibody is affinity chromatography purified via peptide column.

Cat. No. 1319 - Human Stomach Tissue Lysate

1 mg/mL

TRIM5 alpha Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TRIM5 alpha antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Anti-TRIM5 alpha is human reactive but should presumably also react with rhesus protein.

TRIM5

Cat. No. 1317 - Human Uterus Tissue Lysate

Cat. No. 1314 - Human Thymus Tissue Lysate

Cat. No. 10-001 - Human Breast Tissue Slide

Tripartite motif-containing 5

Macaca mulatta

Reymond A, Meroni G, Fantozzi A, et al. The tripartite motif family identifies cell compartments. EMBO J. 2001; 20:2140-51.

Stremlau M, Owens CM, Perron MJ, et al. The cytoplasmic body component TRIM5a restricts HIV-1 infection in Old World monkeys. Nature 2004; 427:848-53.

Hatziioannou T, Perez-Caballero D, Yang A, et al. Retrovirus resistance factors REF1 and Lv1 are species-specific variants of TRIM5α . Proc. Nat'l. Acad. Sci. USA 2004; 101:10774-9

TRIM5 alpha Antibody: RNF88, TRIM5alpha, RNF88, Tripartite motif-containing protein 5, RING finger protein 88

ELISA, WB, IF

110339457

Liquid