TRIM58 Antilichaam

TRIM58 Antibody: TRIM58 is a member of the tripartite motif-containing family of proteins that frequently possess E3 ubiquitin ligase activities (1) . TRIM58 is strongly expressed in erythroid lineage cells and is further upregulated during late erythroid maturation. Recent experiments suggest that TRIM58 facilitates erythroblast enucleation by ubiquitinating the intermediate chain of the microtubule motor dynein, thereby inducing proteolytic degradation (2) .

25893

Q8NG06

NP_056246

Human, Mouse, Rat

TRIM58 antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human TRIM58.

Unconjugated

Primary Antibodies

Stem Cell

TRIM58 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1301 - Human Heart Tissue Lysate

1 mg/mL

TRIM58 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TRIM58 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

TRIM58

Cat. No. 1405 - Mouse Kidney Tissue Lysate

Tripartite motif containing 58

Homo sapiens

Napolitano LM and Meroni G. TRIM family: Pleiotropy and diversification through homomultimer and heteromultimer formation. IUBMB Life 2012; 64:64-71.

Thom CS, Traxler EA, Khandros E, et al. Trim58 degrades dynein and regulates terminal erythropoiesis. Dev. Cell 2014; 30:688-700.

TRIM58 Antibody: Tripartite motif containing 58 protein, BIA2

ELISA, WB

112421127

Liquid