Trim5a-antilichaam [3B11H2]

TRIM5-alpha is a protein that is found in the cells of many mammals and fends of various retrovirus infections. It protects monkeys from infection with HIV-1, and humans from infection with some other viruses. If a retrovirus has entered a cell, it needs to shed its capsid in order to reversely transcribe its genes, so that they can be expressed by the host cell. It is believed that TRIM5α , which is present in the cytoplasm, somehow recognizes the capsid and blocks its shedding, thereby stopping the virus in its tracks. It thus represents an intracellular defense completely separate from the rest of the body's immune system.

85364

Q9NUD5

Q9NUD5

Human

Ni-NTA purified truncated recombinant human trim5 alpha expressed in E. Coli strain BL21 (DE3) .

3B11H2

Unconjugated

Primary Antibodies

Infectious Disease

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

Trim5α monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

ZCCHC3

Zinc finger, CCHC domain containing 3

Homo sapiens

Stremlau, M. Nature 2004.427:848-53.

Song, B. J Virol. 2005.79 (7) :3930-7.

C20orf99C20orf99

WB, IHC

23396534