TRIM71 Antilichaam

TRIM71 Antibody: TRIM71 is the mammalian ortholog to the C. elegans heterochronic protein Lin41, a protein that is thought to be important in postembryonic development, and is genetically and biochemically downstream of both Shh and Fgf signaling pathways. Similar to its C. elegans homolog, TRIM71 is a target of the microRNA let-7 and is likely to play a role in mammalian development. Recent experiments have indicated that TRIM71 is an E3 ubiquitin ligase and can interact with the Dicer and the Argonaute proteins Ago1, Ago2, and Ago4. Overexpression and depletion of TRIM71 led to inverse changes in Ago2 protein levels, suggesting TRIM71 can regulate Ago2 turnover. Finally, TRIM71 cooperates with the pluripotency factor Lin-28 in regulating let-7.

131405

Q2Q1W2

NP_001034200

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

TRIM71 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%), Chicken: (100%)

TRIM71 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TRIM71 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

TRIM71

Cat. No. 10-301 - Human Brain Tissue Slide

Tripartite motif-containing 71

Homo sapiens

Lancman JJ, Caruccio NC, Harfe BD, et al. Analysis of the regulation of lin-41 during chick and mouse limb development. Dev. Dyn.2005; 234:948-60.

Lin YC, Hsieh LC, Kuo MW, et al. Human TRIM71 and its nematode homologue are targets of let-7 microRNA and its zebrafish orthologue is essential for development. Mol. Biol. Evol.2007; 24:2525-34.

Rybak A, Fuchs H, Hadian K, et al. The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. Nat. Cell Biol.2009; 11:1411-20.

TRIM71 Antibody: LIN41, LIN-41, LIN41, E3 ubiquitin-protein ligase TRIM71, Protein lin-41 homolog

ELISA, WB, IHC-P, IF

84993742

Liquid