Trimethidinium (methosulfaat)

Trimethidinium methosulfate is an orally active ganglionic blocker with central antihypertensive activity. Trimethidinium methosulfate inhibits the conduction of sympathetic ganglia and reduces vascular contraction. Trimethidinium methosulfate acts on the cerebrovascular motor center and lowers peripheral vascular resistance. Trimethidinium methosulfate has cholinergic nerve inhibitory side effects, but they are relatively mild. Trimethidinium methosulfate can be used in hypertension research[1][2].

14149-43-0

12352005

Cholinesterase (ChE)

Neuronal Signaling

Cardiovascular Disease

O=S([O-])(OC)=O.CC1(C2CCC1(C[N+](CCC[N+](C)(C)C)(C2)C)C)C.O=S([O-])(OC)=O

C19H42N2O8S2

490.68

[1]PELNER L, WALDMAN S. Trimethidinium methosulfate in the treatment of moderate and severe hypertension. J Am Geriatr Soc. 1960 Mar;8:168-76. |[2]BORHANI NO. Use of trimethidinium methosulfate (a new ganglionic blocking agent) in the treatment of hypertension. Ann Intern Med. 1959 Nov;51:983-92.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-180382/

Reference compound1

No Development Reported