Trimethylamineoxide-15N
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Trimethylamine oxide-15N is the deuterium labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway[1][2][3].
12352211
H302, H332
Reactive Oxygen Species (ROS)
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Inflammation/Immunology
99.93
C[15N+]([O-])(C)C
C3H9 15NO
76.10
H302, H332
[1]Wei Shuai, et al. High-choline Diet Exacerbates Cardiac Dysfunction, Fibrosis, and Inflammation in a Mouse Model of Heart Failure With Preserved Ejection Fraction. J Card Fail. 2020 May 14; S1071-9164 (19) 31802-0.|[2]Wenlong Yang, et al. Gut Microbe-Derived Metabolite Trimethylamine N-oxide Accelerates Fibroblast-Myofibroblast Differentiation and Induces Cardiac Fibrosis. J Mol Cell Cardiol. 2019 Sep;134:119-130.|[3]Manuel T Velasquez, et al. Trimethylamine N-Oxide: The Good, the Bad and the Unknown. Toxins (Basel) . 2016 Nov 8;8 (11) :326.
Room Temperature
4°C (Powder, sealed storage, away from moisture)
http://file.medchemexpress.com/batch_PDF/HY-W722562/Trimethylamine-oxide-15N-SDS-MedChemExpress.pdf
Isotope-Labeled Compounds
No Development Reported
Beschrijving
Trimethylamine oxide-15N is the deuterium labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and ot
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