Trk A (fosfo Tyr757) Antilichaam

Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF) . Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.

4914

P04629

NP_002520.2

Human, Mouse

Trk A (phospho Tyr757) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 757 (E-V-Y (p) -A-I) derived from Human Trk A.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

87 kDa

IgG

The antibody detects endogenous levels of Trk A only when phosphorylated at tyrosine 757.

NTRK1

Neurotrophic tyrosine kinase, receptor, type 1

Homo sapiens

Martin-Zanca D., Mol. Cell. Biol. 9:24-33 (1989) .

Shelton D.L., J. Neurosci. 15:477-491 (1995) .

The MGC Project Team, Genome Res. 14:2121-2127 (2004) .

TRKA, TRK, NTRK1, p140-TrkA

IHC

94730402

Liquid