Trk A (fosfo Tyr791) Antilichaam

Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF) . Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.

4914

P04629

NP_002520.2

Human

Trk A (phospho Tyr791) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 791 (P-V-Y (p) -L-D) derived from Human Trk A.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

140 kDa

IgG

The antibody detects endogenous levels of Trk A only when phosphorylated at tyrosine 791.

NTRK1

Neurotrophic tyrosine kinase, receptor, type 1

Homo sapiens

Tina Garofalo, J. Biol. Chem., Dec 1998; 273: 35153.

Jan Grimm, J. Cell Biol., Jul 2001; 154: 345.

Jose L. Tomsig, J Androl, May 2006; 27: 348 - 357.

VI Shifrin and BG Neel J. Biol. Chem., Dec 1993; 268: 25376 - 25384

TRKA, TRK, NTRK1, p140-TrkA

IHC

94730402

Liquid