TrkB-Fc Chimera, menselijk, gezuiverd Recombinant Proteïne

Tyrosine Kinase Receptor B (TrkB) is a high affinity receptor for brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. It also binds neurotrophin 3 (NT-3) with lower affinity. TrkB does not bind nerve growth factor (NGF) . TrkB is involved in the development and/or maintenance of the nervous system and is widely expressed, predominantly in nervous tissue. TrkB is a heavily glycosylated type I transmembrane protein. The TrkB-Fc chimera contains 13 potential N-linked glycosylation sites.

Tyrosine Kinase Receptor B (TrkB) -Fc Chimera, purified human recombinant protein, suitable for IP and to block.

Tropomyosin-related kinase receptor; BDNF/NT-3 growth factors receptor; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; GP145-TrkB/GP95-TrkB; Trk-B; Ntrk2; Trkb; TrkB-Fc Chimera

Q16620

Tyrosine Kinase Receptor B (TrkB)

A DNA sequence encoding the signal peptide and extracellular domain of human TrkB (amino acids 1- 428) was fused to the Fc region of human IgG1 (amino acids 93-330) . The chimeric protein was expressed in modified human 293 cells.

Block, IP

Purified. The chimera consists of 20-40% carbohydrate by weight.

For research use only.

25°C (ambient)

Reconstitute with sterile-filtered phosphate-buffered saline to a concentration of 20 μg/mL. Lyophilized products should be stored at 2 to 8°C. Following reconstitution, short-term storage at 2-8°C is recommended and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.

>95% purity, as determined by SDS-PAGE and visualized by silver stain.

HEK293

Lyophilized