TrkB (fosfo Tyr705) Antilichaam

Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF) . Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC γ1.

4915

Q16620

NP_001007098.1

Human, Mouse, Rat

TrkB (Phospho-Tyr705) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 705 (T-D-Y P-Y-R) derived from Human TrkB.

Unconjugated

Primary Antibodies

Phospho-Specific, Neuroscience

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

140 kDa

This antibody detects endogenous level of TrkB only when phosphorylated at tyrosine 705.

Western Blot: 1:500~1:1000

NTRK2

Neurotrophic tyrosine kinase, receptor, type 2

Homo sapiens

Woronowicz A, et al. Glycobiology. 2007 Jan;17 (1) : 10-24. Mojsilovic-Petrovic J, et al. J Neurosci. 2006 Sep 6;26 (36) : 9250-63. Lewis MA, et al. Mol Pharmacol. 2006 Apr;69 (4) : 1396-404. Cai D, et al. Physiol Genomics. 2006 Feb 14;24 (3) : 191-7.

TRKB, trk-B, GP145-TrkB, P53, BDNF/NT-3 growth factors receptor precursor, EC 2.7.10.1, GP145-TrkB/GP95-TrkB, NTRK2

WB

55956790

Liquid