Trombomoduline Recombinant eiwit

Thrombomodulin (TM, CD141, THBD) is an endothelial cell expressed transmembrane glycoprotein that can form a complex with the coagulation factor, Thrombin. The Thrombomodulin/Thrombin complex converts protein C to its activated form, protein Ca, which in turn proteolytically cleaves and deactivates factor Va and factor VIIIa, two essential components of the coagulation mechanism. This inactivation reduces the generation of additional thrombin and thereby effectively prevents continued coagulation. Reduced levels of Thrombomodulin can correlate with the pathogenesis of certain cardiovascular diseases, such as atherosclerosis and thrombosis. However, the serum levels of the truncated circulating form of Thrombomodulin are typically elevated during inflammation and in the presence of various inflammatory related diseases. Recombinant soluble Thrombomodulin is a 491 amino acid glycoprotein containing the extracellular domain of Thrombomodulin.

7056

P07204

NP_000352.1

Recombinant Proteins

HEK293 cells

Room Temp

The lyophilized Thrombomodulin recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted Thrombomodulin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing Thrombomodulin recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Thrombomodulin

Homo sapiens

TM, THRM, AHUS6, BDCA3, CD141, THPH12, Thrombomodulin, Fetomodulin, TM

Human

4507483

Lyophilized