Trophinin Antilichaam

Trophinin, also known as TRO or MAGED3, is an apical cell adhesion molecule that is implicated in the initial attachment during the process of embryo implantation and functions by mediating cell adhesion between trophoblastic and endometrial epithelial cells (1,2) . Trophinin is a membrane protein expressed in chorionic villi trophoblasts and in maternal endometrial epithelial cells in an implantation-dependent manner and interacts with Bystin and Tastin, facilitating cell adhesion and embryo implantation (3,4) . The induction of Trophinin expression may be a useful method for improving implantation rates and can be a potential diagnostic factor and biomarker for human cancer (4,5) .

7216

Q12816

NP_001034794

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell, Cancer, Apoptosis

Trophinin antibody is affinity chromatography purified via peptide column.

Cat. No. 1464 - Rat Liver Tissue Lysate

1 mg/mL

Trophinin antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Trophinin antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

Trophinin antibody is human, mouse and rat reactive. Multiple isoforms of Trophinin are known to exist.

TRO

Trophinin

Homo sapiens

Fukuda MN, Sato T, Nakayama J, et al. Trophinin and tastin, a novel cell adhesion molecule complex with potential involvement in embryo implantation. Genes Dev. 1995; 9:1199-210.

Ma L, Yin M, Wu X, et al. Expression of trophinin and bystin identifies distinct cell types in the germinal zones of adult rat brain. Eur. J. Neurosci. 2006; 23:2265-76.

Tamura N, Sugihara K, Akama TO, et al. Trophinin-mediated cell adhesion induces apoptosis of human endometrial epithelial cells through PKC-d. Cell Cycle 2011; 10:135-43.

Chen KY, Lee YC, Lai JM, et al. Identification of trophinin as an enhancer for cell invasion and a prognostic factor for early stage lung cancer. Eur. J. Cancer. 2007; 43:782-90.

TRO, MAGE-d3, MAGED3

ELISA, WB, IHC-P, IF

89276766

Liquid