TRP-1 Antilichaam / Tyrosinase-Verwant Proteïne-1

It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1) . It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-3 µg/mL

P17643

Human

SK-MEL-23 cells were used as the immunogen for the TRP-1 antibody.

SPM456

FACS, IF

Protein A/G affinity

Purified

This TRP-1 antibody is available for research use only.

Aliquot the TRP-1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Optimal dilution of the TRP-1 antibody should be determined by the researcher.

Cytoplasm