TRPC3 Antilichaam

The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the "canonical TRP" (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC3/6/7 subfamily can be activated by diacylglycerol analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. TRPC3 encodes a Ca2+-permeant channel that is agonist-activated but not store-operated or directly receptor-activated. TRPC3 physically interacts with TRPC6 and TRPC7 and forms functional tetrameric channels.

7222

Q13507

NP_001124170

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction, Neuroscience

TRPC3 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1362 - Human Cerebellum Tissue Lysate

1 mg/mL

TRPC3 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TRPC3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

TRPC3 antibody is human, mouse and rat reactive. At least four isoforms are known to exist; this antibody will detect the three largest isoforms. TRPC3 antibody is predicted to not cross-react with TRPC6.

TRPC3

Cat. No. 10-301 - Human Brain Tissue Slide

Transient receptor potential cation channel, subfamily C, member 3

Homo sapiens

Contell C, Birnbaumer V, Flockerzi V, et al. A unified nomenclature for the superfamily of TRP cation channels. Mol. Cell 2002; 9:229-31.

Trebak M, Vazquez G, Bird GSJ, et al. The TRPC3/6/7 subfamily of cation channels. Cell Calcium 2003; 33:451-61.

Zitt C, Obukhov AG, Strubing C, et al. Expression of TRPC3 in Chinese hamster ovary cells results in calcium-activated cation currents not related to store depletion. J. Cell. Biol. 1997; 1333-41.

Dietrich A, Kalwa H, Rost BR, et al. The diacylglycerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance. Pflugers Arch. 2005; 451:72-80.

TRP3, TRP3, Short transient receptor potential channel 3, Transient receptor protein 3, TrpC3

ELISA, WB, IHC-P

194733735

Liquid