TRPC6 Antilichaam

TRPC6 Antibody: The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the "canonical TRP" (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC6/6/7 subfamily can be activated by diacylglycerol (DAG) analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. When expressed in transfected cells, TRPC6 acts as a non-selective store-independent receptor-activated cation channel. It is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation. There is increasing evidence that TRPC6 encodes endogenous DAG-activated receptor-operated cation channels in vivo.

7225

Q9Y210

AAH93658

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction, Neuroscience

TRPC6 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1402 - Mouse Lung Tissue Lysate

1 mg/mL

TRPC6 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TRPC6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

This antibody may cross-react with TRPC3.

TRPC6

Transient receptor potential cation channel, subfamily C, member 6

Homo sapiens

Contell C, Birnbaumer V, Flockerzi V, et al. A unified nomenclature for the superfamily of TRP cation channels. Mol. Cell 2002; 9:229-31.

Dietrich A, Kalwa H, Rost BR, et al. The diacylglycerol-sensitive TRPC6/6/7 subfamily of cation channels: functional characterization and physiological relevance. Pflugers Arch. 2005; 451:72-80.

Trebak M, Vazquez G, Bird GSJ, et al. The TRPC6/6/7 subfamily of cation channels. Cell Calcium 2003; 33:451-61

TRPC6 Antibody: TRP6, FSGS2, TRP6, Short transient receptor potential channel 6, Transient receptor protein 6, TrpC6

ELISA, WB, IHC-P, IF

62739910

Liquid