TRPM4 Mouse Monoclonal Antibody [Kloon ID: LBI10H5]

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca (2+), it is impermeable to it. Mediates transport of monovalent cations (Na (+) > K (+) > Cs (+) > Li (+) ), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca (2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca (2+) overload.

Carrier-free (BSA/glycerol-free) TRPM4 mouse monoclonal antibody, clone LBI10H5

HTRPM4; LTrpC4; PFHB1B; TRPM4B

Homo sapiens transient receptor potential cation channel subfamily M member 4 (TRPM4), transcript variant 1, mRNA.

54795

Q8TD43

Unconjugated

WB 1:5000~10000, IHC 1:50

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

TRPM4

https://www.ncbi.nlm.nih.gov/gene/?term=54795

https://www.uniprot.org/uniprot/Q8TD43