TRPV4 Antilichaam

The transient receptor potential (TRP) protein family consists of a diverse group of cation channels functioning in a variety of homeostatic and regulatory pathways. Four subfamilies exist, based on channel domain homology: C type (canonical), V type (vanilloid receptor related), M type (melastatin related) and P type (PKD) (1) . TRPV4, belongs to the V type subfamily and plays a role in systemic osmoregulation (2,3) . TRPV4 is a calcium channel multi-pass membrane protein activated by various stimuli, including thermal stress, fatty acid metabolites and hypotonicity (3) . TRPV4 is highly expressed in lung and kidney and widely expressed in brain. It plays an important role in regulating neural excitability (4) .

59341

Q9HBA0

NP_067638

Human

Unconjugated

Primary Antibodies

Signal Transduction

TRPV4 antibody is affinity chromatography purified via peptide column.

Cat. No. 1220 - SK-N-SH Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (100%), Mouse: (100%)

TRPV4 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TRPV4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

TRPV4 antibody is human specific. At least six isoforms of TRPV4 are known to exist. This antibody is predicted to not cross-react with other TRP protein family members.

TRPV4

Cat. No. 10-101 - Human Lung Tissue Slide

Transient receptor potential cation channel, subfamily V, member 4

Homo sapiens

Birnbaumer L, Yildirim E and Abramowitz J. A comparison of the genes coding for canonical TRP channels and their M, V and P relatives. Cell Calcium 2003; 33:419-32.

Alessandri-Haber N, Dina OA, Yeh JJ, et al. Transient receptor potential vanilloid 4 is essential in chemotherapy-induced neuropathic pain in the rat. J. Neurosci. 2004; 24:4444-52.

Liedtke W. TRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals. J. Physiol. 2005; 567:53-8.

Shibasaki K, Suzuki M, Mizuno A, et al. Effects of body temperature on neural activity in the hippocampus: regulation of resting membrane potentials by transient receptor potential vanilloid 4. J. Neurosci. 2007; 27:1566–75.

TRPV4 Antibody: SMAL, VRL2, CMT2C, SPSMA, TRP12, VROAC, HMSN2C, OTRPC4, SSQTL1, Transient receptor potential cation channel subfamily V member 4, Osm-9-like TRP channel 4, TrpV4

ELISA, WB, IHC-P, IF

22547184

Liquid