TRX-518
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
TRX-518 is a humanized agonist antibody targeting glucocorticoid-induced tumor necrosis factor receptor (GITR) . TRX-518 specifically targets GITR⁺ Tregs and CD45RA⁻Foxp3⁺ effector Tregs (eTregs) among regulatory T cells (Tregs), reducing the number of Tregs in circulation and within tumors. TRX-518 is promising for research of cancers[1].
12352203
TNF Receptor
Apoptosis
Cancer-programmed cell death
Cancer
98.58
[3H][R][X518]
(145.26 kDa)
[1]Zappasodi R, et al. Abstract CT018: Intratumor and peripheral Treg modulation as a pharmacodynamic biomarker of the GITR agonist antibody TRX-518 in the first in-human trial[J]. Cancer Research, 2017, 77 (13_Supplement) : CT018-CT018.
Dry Ice
-80°C
http://file.medchemexpress.com/batch_PDF/HY-P991180/TRX-518-SDS-MedChemExpress.pdf
Inhibitory Antibodies
Phase 1
Beschrijving
TRX-518 is a humanized agonist antibody targeting glucocorticoid-induced tumor necrosis factor receptor (GITR) . TRX-518 specifically targets GITR⁺ Tregs and CD
Specificaties
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