TSC22D3 Antilichaam

TSC22D3 Antibody: The TSC22 domain family member 3 protein (TSC22D3) is a leucine zipper protein that functions as a transcriptional regulator. The expression of TSC22D3 is stimulated by glucocorticoids and IL-10 and is thought to play a key role in the anti-inflammatory and immunosuppressive effects of these molecules. TSC22D3 can physically interact with and inhibit the activities of key inflammatory signaling mediators such NF-κ B and AP-1. TSC22D3 functions as a transcriptional co-activator for various nuclear receptors and NF-κ B. It has also been shown to be involved in the differentiation of mesenchymal stem cells towards osteoblasts and bone formation.

1831

Q99576

NP_932174

Human, Mouse

Unconjugated

Primary Antibodies

Stem Cell

TSC22D3 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1308 - Human Small Intestine Tissue Lysate

1 mg/mL

TSC22D3 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TSC22D3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

TSC22D3

Cat. No. 11-801 - Human Small Intestine Tissue Slide

TSC22 domain family, member 3

Homo sapiens

Riccardi C, Cifone MG, and Migliorati G. Glucocorticoid hormone-induced modulation of gene expression and regulation of T-cell death: role of GITR and GILZ, two dexamethasone-induced genes. Cell Death Differ. 1999; 6:1182-9.

Berrebi D, Bruscoli S, Cohen N, et al. Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10. Blood 2003; 101:729-38

Ayroldi E, Migliorati G, Bruscoli S, et al. Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB. Blood 2001; 98:743-53.

Mittelstadt PR and Ashwell JD. Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ. J. Biol. Chem. 2001; 276:29603-10.

TSC22D3 Antibody: DIP, GILZ, hDIP, DSIPI, TSC-22R, TSC22 domain family protein 3, DSIP-immunoreactive peptide, Protein DIP

ELISA, WB, IHC-P, IF

37622903

Liquid