TSLP-antilichaam

TSLP Antibody: Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. TSLP is a four-helix-bundle cytokine that is expressed mainly by barrier epithelial cells and is a potent activator of several cell types such as myeloid dendritic cells. TSLP is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Amino acid sequence analysis has shown poor homology between human and mouse TSLP although they exhibit similar biological functions and are expressed in similar tissues. At least two differentially spliced isoforms of TSLP are known to exist.

85480

Q969D9

NP_149024

Human

4021

Unconjugated

Primary Antibodies

Recombinant Protein Validation (Figure 1) : Anit-TSLP antibodies (4021) detected human TSLP recombinant protein at different concentrations. Recombinant Protein Validation4021 Regulated Expression Validation (Figure 4-8) : Anit-TSLP antibodies (4021) detected increased expression in multiple tissue or cells after treatment with cytokines or chemicals, in which the increase in the expression was inhibited by co-treatment with anti-cholinergic drugs (Figure 5) . Regulated Expression Validation4021

Immunology

TSLP Antibody is affinity chromatography purified via peptide column.

Cat. No. 1205 - Jurkat Cell Lysate

1 mg/mL

TSLP Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TSLP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human TSLP has 2 isoforms, including isoform 1 (159aa, 18kD) and isoform 2 (63aa, 7kD) . Mouse TSLP has one isoform (140aa, 16kD) and rat TSLP also has one isoform (135aa, 16kD) . 4021 can detect only human isoforms, but cannot detect mouse and rat TSLP.

TSLP

Cat. No. 1303 - Human Brain Tissue Lysate

Cat. No. 10-301 - Human Brain Tissue Slide

Thymic stromal lymphopoietin

Homo sapiens

Ziegler and Liu. Nature Immunol. 2006; 7:709-14.

Sims et al. J. Exp. Med. 2000; 192:671-80.

Levin et al. J. Immunol. 1999; 162:677-83.

Quentmeier et al. Leukemia 2001; 15:1286-92.

PMID: 24850429.

PMID: 30291224.

PMID: 29803543.

PMID: 23550226.

PMID: 24381572.

PMID: 21820713.

PMID: 20107175.

PMID: 19151401.

TSLP Antibody: Thymic stromal lymphopoietin

ELISA, WB, IHC-P

14719428

Liquid