TTYH2 Antilichaam

TTYH2 Antibody: TTYH2 is a member of the tweety family of proteins, a family of chloride anion channels containing five transmembrane regions. TTYH2 is a Ca2+-activated large conductance chloride (Cl-) channel and may play a role in kidney tumorigenesis. It is also upregulated in colon carcinoma and is thought to play a role in cell proliferation and call aggregation, suggesting that TTYH2 may play a role in regulating both proliferation and metastatic potentials of colorectal cancer. The ubiquitin-protein ligase Nedd4-2 binds to and ubiquitinates TTYH2, thereby regulating its cell surface expression and total cellular levels.

94015

Q9BSA4

NP_116035

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

TTYH2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1305 - Human Kidney Tissue Lysate

1 mg/mL

TTYH2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TTYH2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least four isoforms of TTYH2 are known to exist; this antibody will only detect the two longest isoforms. This antibody is predicted to not cross-react with other TTYH family members.

TTYH2

Cat. No. 10-401 - Human Kidney Tissue Slide

Tweety homolog 2 (Drosophila)

Homo sapiens

Rae FK, Hooper JD, Eyre HJ, et al. TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma. Genomics 2001; 77:200-7.

Toiyama Y, Mizoguchi A, Kimura K, et al. TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation. World J. Gastroenterol. 2007; 13:2717-21

He Y, Hryciw DH, Carroll ML, et al. The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels. J. Biol. Chem. 2008; 283:24000-10.

TTYH2 Antibody: C17orf29, C17orf29, Protein tweety homolog 2, hTTY2

ELISA, WB, IHC-P, IF

53988385

Liquid