Tubastatine A · HCl
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Tubastatin A is a potent and highly selective inhibitor of HDAC6 (IC50 = 15 nM, >1000-fold selectivity against other HDAC isoforms, approx. 60-fold versus HDAC8) .1 It displayed anti-inflammatory and anti-rheumatic effects in Freund’s competitive adjuvant induced animal model of inflammation.2 Tubastatin A inhibited TNF-α (IC50 = 272 nM) and IL-6 (IC50 = 712 nM) in LPS stimulated human THP-1 macrophages.2 Tubastatin A has also been shown to have therapeutic potential for treatment of Alzheimers disease via altered amloid-β load and reduced tau hyperphosphorylation.3,4,5
Unconjugated
Solid
-20°C
Beschrijving
Tubastatine A · HCl Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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