TWEAK Antilichaam

TWEAK Antibody: TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane. TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis, induction of inflammatory cytokines, in addition to stimulation of apoptosis. The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains.

8742

O43508

NP_003800

Human, Mouse

3791

Unconjugated

Primary Antibodies

Recombinant Protein Test (Figure 2) : Anti-TWEAK antibodies (3791) detected human TWEAK recombinant protein at different concentrations. Recombinant Protein Test3791

Apoptosis, Cancer

TWEAK Antibody is Protein A-purified.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

TWEAK Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TWEAK antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human TWEAK has 2 isoforms, including isoform 1 (249aa, 27kD) and isoform 2 (330aa, 36kD) . Mouse TWEAK has one isoform (249aa, 27kD) and Rat TWEAK also has one isoform (249aa, 27kD) .

TNFSF12

Cat. No. 1201 - HeLa Cell Lysate

Cat. No. 10-301 - Human Brain Tissue Slide

Tumor necrosis factor (ligand) superfamily, member 12

Homo sapiens

Wiley and Winkles. Cyto. And Growth Factor Rev. 2003; 14:241-9.

Chicheportiche et al. J. Biol. Chem. 1997; 272:32401-10.

Lynch et al. J. Biol. Chem. 1999; 274:8455-9.

Chicheportiche et al. Arthr. Res. 2002; 4:126-33. 5.

TWEAK Antibody: APO3L, DR3LG, TWEAK, APO3L, UNQ181/PRO207, Tumor necrosis factor ligand superfamily member 12, APO3 ligand

ELISA, WB, IHC-P, IF

4507597

Liquid