TWEAK receiver, oplosbaar

TWEAK-R belongs to the TNF family of transmembrane proteins and contains a cytoplasmic „death domain“, which can activated the cell's apoptotic machinery. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAK-R can be activated by either the membrane anchored or the soluble TWEAK. Recombinant soluble TWEAK-R is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full length TWEAK-R protein.

TNFRSF12A; FN14; CD266; TWEAKR

51330

Q9NP84

NP_057723.1

NM_016639.2

16p13.3

Human

Human

EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP

< 0.1 ng/µg of protein (< 1EU/µg)

> 98% by SDS-PAGE & HPLC analyses

Determined by its ability to inhibit TWEAK-induced weak cell death of HT29 cells. The expected ED50 for this effect is 1.0-3.0 µg/ml.

53

Lyophilized

5.6 kDa

E. coli