TWEAK Recombinant eiwit

TWEAK belongs to the TNF family of ligands and signals through TWEAKR also known as TNFRSF12A. TWEAK is expressed in a variety of tissues, including the adult heart, pancreas, skeletal muscle, small intestine, spleen and peripheral blood lymphocytes. TWEAK has the ability to induce NFkB activation and chemokine secretion, and to exert an apoptotic activity in certain cells, such as HT-29 human adenocarcinoma cells when cultured in the presence of IFN-γ . TWEAK also promotes proliferation and migration of endothelial cells. Recombinant human TWEAK is a soluble 17.0 kDa polypeptide (154 amino acid residues) comprising the TNF homologous region of TWEAK and is generated by proteolytic processing of the full length membrane anchored TWEAK protein.

8742

O43508

NP_003800.1

Recombinant Proteins

E. coli

Apoptosis, Cancer, Chemokines & Cytokines, Other

Room Temp

The lyophilized TWEAK recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted TWEAK is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing TWEAK recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Tumor necrosis factor (ligand) superfamily, member 12

Homo sapiens

APO3L, DR3LG, TWEAK, APO3L, UNQ181/PRO207, Tumor necrosis factor ligand superfamily member 12, APO3 ligand

Human

4507597

Lyophilized