Twist1 Antilichaam

Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation.

7291

Q15672

NP_000465.1

Human, Mouse, Rat

Twist1 antibody was raised against a peptide sequence around aa.18~22 (S-N-S-E-E) derived from Human Twist1.

Unconjugated

Primary Antibodies

Stem Cell

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

28 kDa

This antibody detects endogenous levels of total Twist1 protein.

Western Blot: 1:500~1:1000

TWIST1

Twist family bHLH transcription factor 1

Homo sapiens

"Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. "Sosic D., Richardson J. A., Yu K., Ornitz D. M., Olson E. N. Cell 112:169-180 (2003) "Mutations of the TWIST gene in the Saethre-Chotzen syndrome. "el Ghouzzi V., le Merrer M., Perrin-Schmitt F., et al., Nat. Genet. 15:42-46 (1997)

CRS, SCS, ACS3, CRS1, BPES2, BPES3, TWIST, bHLHa38

WB

4507741

Liquid