TYK2 Antilichaam

TYK2 Antibody: TYK2 is a member of the Janus kinases (JAKs) protein families. TYK2 associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits and is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

7297

P29597

NP_003322

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

TYK2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1308 - Human Small Intestine Tissue Lysate

1 mg/mL

TYK2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

TYK2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Predicted: 131 kDa

IgG

At least three isoforms of TYK2 are known to exist; this antibody only detects the two longest isoforms.

TYK2

Tyrosine kinase 2

Homo sapiens

Strobl B, Stoiber D, Sexl V, et al. Tyrosine kinase 2 (TYK2) in cytokine signalling and host immunity. Front. Biosci. 2011; 17:3214-32.

TYK2 Antibody: JTK1, Non-receptor tyrosine-protein kinase TYK2

ELISA, WB, IF

187608615

Liquid