TYK2 (NM 003331) Humaan Recombinant eiwit

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35. [provided by RefSeq, Sep 2020]

Purified recombinant protein of Human tyrosine kinase 2 (TYK2), Arg240-Val387, with N-terminal His-ABP tag, expressed in E. coli, 50ug

IMD35; JTK1

7297

P29597, A0A024R7E4

NM_003331

19p13.2

E. coli

N-His-ABP

Jak-STAT signaling pathway

Jak-STAT signaling pathway

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol.

Druggable Genome, Protein Kinase

31.3 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

TYK2

Human

NP_003322

https://www.ncbi.nlm.nih.gov/gene/7297

https://www.uniprot.org/uniprot/P29597

https://www.ncbi.nlm.nih.gov/nuccore/NM_003331

https://www.ncbi.nlm.nih.gov/nuccore/NP_003322