TYRO3 Antilichaam [1C10E8 / 9A3F2]

Tyrosine-protein kinase (TYRO3) belongs to the Tyr protein kinase family (AXL/UFO subfamily) . The UFO family of receptor tyrosine kinases is comprised of subfamily members Rse (also referred to as Tyro3 or Sky) and UFO (also called Tyro7 or Axl) . Two distinct isoforms of Rse, designated Brt and Etk-2, have been described. Brt differs from Rse at its C-terminus, but more importantly lacks the N-terminal 31 amino acid signal peptide sequence present in Rse, which is replaced by a 27 amino acid Brt-specific sequence. It has been suggested that as a result of this alternative splicing event, Brt resides in the cytoplasm, unlike Rse which is expressed on the cell surface. Ekt-2 also lacks an N-terminal signal peptide which is substituted with a 45 amino acid Ekt-2-specific sequence. Protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation.

7301

Q06418

Q06418

Human

Ni-NTA purified truncated recombinant TYRO3 expressed in E. Coli strain BL21 (DE3) .

1C10E8 / 9A3F2

Unconjugated

Primary Antibodies

Signal Transduction, Neuroscience

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

TYRO3 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

TYRO3

TYRO3 protein tyrosine kinase

Homo sapiens

Janssen, J.W.G., et al. 1991. Oncogene 6: 2113-2120.

Schlessinger, J., et al. 1992. Neuron 9: 383-391.

Biesecker, L.G., et al. 1995. Oncogene 10: 2239-2242.

BYK, DTK, RSE, SKY, TIF, Tyrosine-protein kinase BYKBYK, Dtk, Sky, Tif

ELISA, WB, IF

1717829