UBD-antilichaam

UBD, also designated ubiquitin D or diubiquitin, plays a role in antigen presentation, cytokine response and apoptosis. It is a 165 amino acid protein encoded in the major histocompatibility complex (MHC) that consists of two domains which share significant homology with ubiquitin (1,2) . UBD is inducible by interferon gamma and TNF-alpha and regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha (3) . It may also regulate cell growth during dendritic cell or B cell activation and development (4,5) .

10537

O15205

NP_006389

Human

Unconjugated

Primary Antibodies

Apoptosis, Immunology

UBD antibody is affinity chromatography purified via peptide column.

Cat. No. 1313 - Human Testis Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (81%)

UBD antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

UBD antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

UBD antibody is human specific.

UBD

Cat. No. 11-701 - Human Testis Tissue Slide

Ubiquitin D

Homo sapiens

Ocklenburg F, Moharregh-Khiabani D, Geffers R, et al. UBD, a downstream element of FOXP3, allows the identification of LGALS3, a new marker of human regulatory T cells. Lab. Invest. 2006; 86:724-37.

Cook WJ, Jeffrey LC, Carson M, et al. Structure of a diubiquitin conjugate and a model for interaction with ubiquitin conjugating enzyme (E2) . J. Biol. Chem. 1992; 267:16467-71.

Rahighi S, Ikeda F, Kawasaki M, et al. Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation. Cell 2009;136:1098-109.

Cort L, Habib M, Eberwine RA, et al. Diubiquitin (Ubd) is a susceptibility gene for virus-triggered autoimmune diabetes in rats. Genes Immun. 2014; 15:168-75.

Ubiquitin D, Diubiquitin, FAT10, GABBR1, UBD-3, Ubiquitin-like protein FAT10

ELISA, WB, IHC-P, IF

222352096

Liquid