UBE1C (UBA3) Mouse Monoclonal Antibody [Kloon ID: LBI3F9]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Carrier-free (BSA/glycerol-free) UBA3 mouse monoclonal antibody, clone LBI3F9

HUBA3; NAE2; UBE1C

Homo sapiens ubiquitin like modifier activating enzyme 3 (UBA3), transcript variant 1, mRNA.

9039

Q8TBC4

Unconjugated

Ubiquitin mediated proteolysis

Ubiquitin mediated proteolysis

WB 1:500

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

UBA3

https://www.ncbi.nlm.nih.gov/gene/?term=9039

https://www.uniprot.org/uniprot/Q8TBC4