UBE2D2 Antilichaam

Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub) -proteasome system (UPS) . An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5) . Alternative splicing results in multiple transcript variants of this gene.

7322

P62837

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human UBE2D2 (NP_003330.1) .

Unconjugated

Primary Antibodies

Cell Cycle

Affinity purification

U-87MG

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 17kDa

IgG

WB: 1:500 - 1:2000

UBE2D2

K-562

293T

Jurkat

Mouse testis

Mouse brain

Ubiquitin-conjugating enzyme E2D 2

Homo sapiens

UBE2D2, E2 (17) KB2, PUBC1, UBC4, UBC4/5, UBCH5B

WB

Liquid