UBE2D3 Antilichaam - N-terminaal gebied: Biotine (ARP43009 P050-Biotine)

Ubiquitin-conjugating enzyme E2D 3

UBC4/5, UBCH5C, E2 (17) KB3

7323

P61077

NP_003331

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

The immunogen is a synthetic peptide directed towards the N terminal region of human UBE2D3

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2D3 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Multiple spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.

NHLRC1; DTX2; TRIM63; RNF146; RNF26; RBX1; UBC; RNF5; RNF2; NEDD4; MID1; STUB1; TRIM39; OTUB1; MDM2; RNF111; TRIM33; PRPF19; RNF115; TRIM58; BTRC; MARCH7; NFKBIA; ARIH1; FBXW11; UBE2D3; PARK2; BRCA1; BARD1; UBE3A; MSL1; UBA1; CBLC; SMURF1; RNF130; UBA6; M

Biotin

Polyclonal Antibody

WB

Affinity Purified

UBE2D3 is strongly supported by BioGPS gene expression data to be expressed in HEK293T, Jurkat, MCF7

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 92%; Rat: 100%; Yeast: 92%; Zebrafish: 92%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

17kDa

Hattori, H., (2007) Blood 110 (2), 640-650

Wet Ice

147

UBE2D3

UBE2D3

Rabbit

Ubiquitin-conjugating enzyme E2 D3

NM_003340

MALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVF