UBE2K Antilichaam - middengebied: FITC (ARP58012_P050-FITC)

Ubiquitin-conjugating enzyme E2K

LIG, HIP2, HYPG, UBC1, E2-25K

3093

P61086

NP_005330

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human UBE2K

UBE2K belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene.

DDI1; DTX3; MIPOL1; TRIM39; ANAPC11; RNF138; SIAH1; RNF5; REL; FZR1; UBC; UBA1; MARCH7; AMFR; TP53; MDM2; BAG3; PRRG4; IQCB1; HTT; CDC6; WDR1; TYMS; TXN; TXNDC17; WDR61; ITCH; NEDD4L; WWP2; NXF1; NUB1; PIAS4; CASP12; SUMO1; SUMO2; DIABLO; UBE2I; CCNB1; BR

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

22kDa

Christensen, D.E., (2007) Nat. Struct. Mol. Biol. 14 (10), 941-948

Wet Ice

200

UBE2K

UBE2K

Rabbit

Ubiquitin-conjugating enzyme E2 K

NM_005339

TVLLSLQALLAAAEPDDPQDAVVANQYKQNPEMFKQTARLWAHVYAGAPV