UBE2N Antilichaam - middengebied: FITC (ARP33126 T100-FITC)

Ubiquitin-conjugating enzyme E2N

UBC13, UbcH13, HEL-S-71, UbcH-ben, UBCHBEN; UBC13

7334

P61088

NP_003339

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Sheep, Yeast, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human UBE2N

UBE2N encodes a member of the E2 ubiquitin-conjugating enzyme family. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. Studies in mouse suggest that this protein plays a role in DNA postreplication repair.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair.

TRIM33; BFAR; MALT1; STUB1; BCL10; UBE2V2; UBC; TRAF6; ZNRF1; XIAP; SLX8; SLX5; MARCH7; TNF; UBE2N; RNF168; RNF8; PARK2; OTUB1; ARIH1; NEDD4L; MFN2; TRIM72; PELI3; RNF111; RNF11; BAG3; TRAF2; FN1; VCAM1; RNF126; RNF115; NBN; ATP6V1H; VPS33B; ZDHHC5; ACTR2

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

IHC, WB

UBE2N is strongly supported by BioGPS gene expression data to be expressed in Jurkat

0.5 mg/ml

Cow: 100%; Dog: 100%; Goat: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Yeast: 100%; Zebrafish: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

17kDa

Zhang, M., (2005) Mol. Cell 20 (4), 525-538

Wet Ice

152

UBE2N

UBE2N

Rabbit

Ubiquitin-conjugating enzyme E2 N

NM_003348

GRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNE