UBE4B Antilichaam - N-terminaal gebied: Biotine (ARP54552 P050-Biotine)

Ubiquitination factor E4B

E4, UFD2, HDNB1, UBOX3, UFD2A

10277

O95155

NP_001099032

Human, Dog, Pig

The immunogen is a synthetic peptide directed towards the N terminal region of human UBE4B

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE4B is an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. The gene that encodes the protein is also the strongest candidate in the neuroblastoma tumor suppressor genes. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

TRIP12; UBC; FBXW11; HGS; STAM; TP53; MDM2; NUSAP1; NUDCD3; RBM12; PDE3A; CDKN2A; UBL7; UBE2D3; CDC27; TTK; IGBP1; HDLBP; TTC9C; MRPL53; ZFYVE19; SARNP; SRPRB; VPS35; UBA6; VPS29; UFM1; SBDS; VPS36; UBQLN1; UBXN7; UBE2C; AHCYL1; SSSCA1; SF3B4; PPIF; SCO2

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Dog: 79%; Human: 100%; Pig: 79%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

146kDa

Olsen, J.V., (2006) Cell 127 (3), 635-648

Wet Ice

1302

UBE4B

UBE4B

Rabbit

Ubiquitin conjugation factor E4 B

NM_001105562

SPMFCSVASFGASSLSSLYESSPAPTPSFWSSVPVMGPSLASPSRAASQL