UBR2 Antilichaam - C-terminaal gebied: Biotine (ARP43188 P050-Biotin)

Ubiquitin protein ligase E3 component n-recognin 2

C6orf133, bA49A4.1, dJ242G1.1, dJ392M17.3

23304

Q8IWV8

NP_056070

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the C terminal region of human UBR2

Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron.Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron (Kwon et al., 2003 [PubMed 14585983]) .[supplied by OMIM].

Vif; UBC; UBE2H; RECQL4; HIST1H2BG; HIST2H2AC; TIRAP; UBE2Z; UBXN1; UBXN7; FAF2; FAF1; UBE2B; MYC; HNRNPA1

Biotin

Polyclonal Antibody

WB

Affinity Purified

There is BioGPS gene expression data showing that UBR2 is expressed in MCF7

0.5 mg/ml

Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 93%; Zebrafish: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

200kDa

Zenker, M., (2005) Nat. Genet. 37 (12), 1345-1350

Wet Ice

1755

UBR2

UBR2

Rabbit

E3 ubiquitin-protein ligase UBR2

NM_015255

QGLRRGNPLHLCKERFKKIQKLWHQHSVTEEIGHAQEANQTLVGIDWQHL