UBTF Antilichaam - middelste regio: FITC (ARP33480_P050-FITC)

Upstream binding transcription factor, RNA polymerase I

UBF, UBF1, UBF2, UBF-1, CONDBA, NOR-90

7343

P17480

NP_055048

Human, Mouse, Rat, Cow, Guinea Pig, Horse, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human UBTF

UBTF is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1. Two UBTF polypeptides, of 94 and 97 kD, exist in the human. UBTF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxesUpstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and multiple TBP-associated factors or 'TAFs') . Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988 [PubMed 3413483]) . UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes (Jantzen et al., 1990 [PubMed 2330041]) .[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

UBC; MDM2; RNF2; Dlg4; ESR1; CDK4; CDK2; CCNE1; CCND1; WDR70; YEATS4; RB1; GRK5; KAT5; SIRT7; POLR1A; MYBBP1A; HDAC1; RUNX2; SUMO2; SMARCA5; MAPK3; MAPK1; SUMO1; PIK3CA; IRS1; TAF1D; tat; MCRS1; TLE1; ACTN4; POLR1E; CHGB; SMURF1; TCOF1; MAD1L1; ZMYM2; SER

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

UBTF is supported by BioGPS gene expression data to be expressed in HeLa

0.5 mg/ml

Cow: 86%; Guinea Pig: 79%; Horse: 77%; Human: 100%; Mouse: 93%; Pig: 86%; Rabbit: 93%; Rat: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

89kDa

Prieto, J.L. (2007) Genes Dev. 21 (16), 2041-2054

Wet Ice

764

UBTF

UBTF

Rabbit

Nucleolar transcription factor 1

NM_014233

LESLPEEEQQRVLGEEKMLNINKKQATSPASKKPAQEGGKGGSEKPKRPV