UCMA Antilichaam

UCMA Antibody: UCMA is a secreted cartilage-specific protein that was discovered in a screen for differentially expressed genes in retinoic acid-treated mouse chondrocytes. It was also identified in a human chondrocyte EST screen for candidate genes of skeletal dysplasias. UCMA expression is thought to parallel that of collagen II with its expression decreasing with maturation chrondrocytes mature. UCMA is processed by a furin-like protease into two fragments, an amino-terminal fragment and a carboxy-terminal fragment (UCMA-C) . Application of recombinant UCMA-C to primary osteoblasts, mesenchymal stem cells, and MC3T3-E1 pre-osteoblasts interferes with their osteogenic differentiation, but does not affect expression of chondrocyte-specific genes or chondrocyte proliferation, suggesting that UCMA may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells. At least two isoforms of UCMA are known to exist.

221044

Q8WVF2

NP_660357

Human, Mouse

Unconjugated

Primary Antibodies

Stem Cell

UCMA Antibody is affinity chromatography purified via peptide column.

Cat. No. 1214 - SW1353 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (81%)

UCMA Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

UCMA antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

UCMA

Upper zone of growth plate and cartilage matrix associated

Homo sapiens

Surmann-Schmitt C, Dietz U, Kireva T, et al. Ucma, a novel secreted cartilage-specific protein with implications in osteogenesis. J. Biol. Chem.2008; 283:7082-93.

Tagariello A, Luther J, Streiter M, et al. Ucma - a noel secreted factor represents a highly specific marker for distal chondrocytes. Matrix Biol.2008; 27:3-11.

UCMA Antibody: GRP, C10orf49, Unique cartilage matrix-associated protein, Gla-rich protein, Ucma-C

ELISA, WB

50400088

Liquid