UGT1A1 Antilichaam - middengebied: Biotine (ARP44294_T100-Biotine)

UDP glucuronosyltransferase 1 family, polypeptide A1

GNT1, UGT1, UDPGT, UGT1A, HUG-BR1, BILIQTL1, UDPGT 1-1

54658

P22309

NP_000454

Human, Mouse, Rat, Cow, Horse, Pig, Rabbit, Sheep

The immunogen is a synthetic peptide directed towards the middle region of human UGT1A1

UGT1A1 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids.This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

COPZ1; SEC23B; UGDH; B3GALT1

Biotin

Polyclonal Antibody

WB

0.5 mg/ml

Cow: 86%; Horse: 86%; Human: 100%; Mouse: 93%; Pig: 86%; Rabbit: 86%; Rat: 86%; Sheep: 86%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

57kDa

Wasmuth, H.E., (2006) Hepatology 43 (4), 738-741

Wet Ice

533

UGT1A1

UGT1A1

Rabbit

UDP-glucuronosyltransferase 1-1

NM_000463

ASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH