UK-224671
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
UK-224671 is a potent and selective NK2 receptor antagonist. UK-224671 is affected by P-gp efflux and poor intrinsic membrane permeability, resulting in low oral bioavailability[1].
178309-91-6
12352005
Neurokinin Receptor
GPCR/G Protein; Neuronal Signaling
Others
O=S(N1CCN(C2CN(CC[C@@](CC3)(C4=CC=C(Cl)C(Cl)=C4)CN(CC5CC5)C3=O)C2)CC1)(C)=O
C25H36Cl2N4O3S
543.55
[1]Beaumont K, et al. The role of P-glycoprotein in determining the oral absorption and clearance of the NK2 antagonist, UK-224,671. Eur J Pharm Sci. 2000 Nov;12 (1) :41-50.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-19405/
Reference compound1
Phase 1
NK2R
Beschrijving
UK-224671 is a potent and selective NK2 receptor antagonist. UK-224671 is affected by P-gp efflux and poor intrinsic membrane permeability, resulting in low ora
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