ULK2 Antilichaam

ULK2 Antibody: ULK2, also known as ATG1B, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK2 results in a severe defect in the autophagy pathway. ULK2 is highly conserved among eukaryotes and shows high homology with its related protein ULK1. Both ULK1 and ULK2 form a complex with ATG13 and FIP200 that mediates TOR signaling and is essential for autophagy. Like ULK1, ULK2 is also thought to be involved in early neuronal growth and differentiation.

9706

Q8IYT8

NP_055498

Human

Unconjugated

Primary Antibodies

Autophagy

ULK2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (82%)

ULK2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ULK2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

At least two isoforms of ULK2 are known to exist; this antibody will detect both isoforms. ULK2 antibody is predicted to not cross-react with ULK1.

ULK2

Cat. No. 10-301 - Human Brain Tissue Slide

Unc-51-like kinase 2 (C. elegans)

Homo sapiens

Suzuki K, Kubota Y, Sekito T, et al. Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes to Cells 2007; 12:209–18.

Lee EJ and Tournier C. The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy. Autophagy 2011; 7:689-95.

Jung CH, Jun CB, Ro SH, et al. ULK-ATG13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol. Biol. Cell 2009; 20:1992-2003.

Zhou X, Babu JR, da Silva S, et al.Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons. Proc. Natl. Acad. Sci. USA 2007; 104:5842-7.

ULK2 Antibody: ATG1B, Unc51.2, KIAA0623, Unc-51-like kinase 2

ELISA, WB, IHC-P, IF

217330557

Liquid