UNC8900

UNC8900 is a VHL recruiting STING PROTAC degrader (DC50: 0.0.924 μM) . UNC8900 can be used for research of viral or bacterial infection. (Blue: VHL ligand, black: linker; Pink: STING inhibitor) [1].

12352005

PROTACs; STING

Reference compound

Immunology/Inflammation; PROTAC

COVID-19-anti-virus

Infection

https://www.medchemexpress.com/unc8900.html

10 mM in DMSO

O=C(C1=CC2=C(N(C(NC(C3=CC(C)=NN3CC)=O)=N2)C/C=C/CN4C(NC(C5=CC(C)=NN5CC)=O)=NC6=C4C(OCCCN7CCOCC7)=CC(C(N)=O)=C6)C(OC)=C1)NCCOCCOCCOCCOCCC(N[C@H](C(C)(C)C)C(N8[C@@H](C[C@@H](O)C8)C(NCC9=CC=C(C%10=C(N=CS%10)C)C=C9)=O)=O)=O

C75H99N17O15S

1510.76

[1]Zhu Z, et al. Development of VHL-recruiting STING PROTACs that suppress innate immunity. Cell Mol Life Sci. 2023 May 14;80 (6) :149.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-158047/

Reference compound1

No Development Reported