UNC8969
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
TAM Receptor
Tyrosine Kinase/Adaptors
UNC8969 is a macrocyclic dual MERTK/AXL inhibitor (IC50 MERTK = 1.1 nM; IC50 AXL = 5.3 nM) . The compound exhibits low nanomolar activity against MERTK and AXL while demonstrating good selectivity over TYRO3 and FLT3. Target binding and selectivity have been confirmed through NanoBRET and cell-based MERTK and AXL phosphorylation assays. UNC8969 possesses excellent pharmacokinetic properties (large AUC and long half-life) and shows exceptional anti-tumor activity against lung cancer cell lines, indicating its potential as a therapeutic compound.
CC1=CC=C(N2)C=C1OC/C=C\CNC3=NC2=C(C(N[C@@H]4CC[C@@H](C(NCCN(CC)CC)=O)CC4)=O)C=N3
C29H41N7O3
535.68
Ice Packs
-20°C
Beschrijving
UNC8969 Beschikbaar in 10 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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