UNC8969

UNC8969 (compound 43) is a MERTK/AXL dual inhibitor with IC50s of 1.1±0.8 nM for MERTK and 5.3 ± 2.7 nM for AXL. UNC8969 also exerts a T1/2 of 7.3 h with 5 mg/kg i.v. in mice[1].

3036049-17-6

12352005

TAM Receptor

Reference compound

Protein Tyrosine Kinase/RTK

Cancer-programmed cell death

Cancer

https://www.medchemexpress.com/unc8969.html

10 mM in DMSO

O=C(C1=C2NC3=CC=C(C(OC/C=C\CNC(N=C1)=N2)=C3)C)N[C@@H]4CC[C@H](CC4)C(NCCN(CC)CC)=O

C29H41N7O3

535.68

[1]Discovery of Novel Macrocyclic MERTK/AXL Dual Inhibitors. J Med Chem. 2024 Apr 11;67 (7) :5866-5882.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-162406/

Reference compound1

No Development Reported