UNC8969
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
UNC8969 (compound 43) is a MERTK/AXL dual inhibitor with IC50s of 1.1±0.8 nM for MERTK and 5.3 ± 2.7 nM for AXL. UNC8969 also exerts a T1/2 of 7.3 h with 5 mg/kg i.v. in mice[1].
3036049-17-6
12352005
TAM Receptor
Reference compound
Protein Tyrosine Kinase/RTK
Cancer-programmed cell death
Cancer
https://www.medchemexpress.com/unc8969.html
10 mM in DMSO
O=C(C1=C2NC3=CC=C(C(OC/C=C\CNC(N=C1)=N2)=C3)C)N[C@@H]4CC[C@H](CC4)C(NCCN(CC)CC)=O
C29H41N7O3
535.68
[1]Discovery of Novel Macrocyclic MERTK/AXL Dual Inhibitors. J Med Chem. 2024 Apr 11;67 (7) :5866-5882.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-162406/
Reference compound1
No Development Reported
Beschrijving
UNC8969 (compound 43) is a MERTK/AXL dual inhibitor with IC50s of 1.1±0.8 nM for MERTK and 5.3 ± 2.7 nM for AXL. UNC8969 also exerts a T1/2 of 7.3 h with 5 mg/k
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