UNG1 Antilichaam

UNG1 Antibody: The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promotes and alternative splicing. While UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from nuclear DNA that arise through either misincorporation during replication or cytosine deamination, inhibition of UNG1 by uracil glycosylase inhibitor did not lead to increased levels of spontaneous or induced mitochondrial DNA mutations. However, decreased levels of UNG activity and increased oxidative damage to mitochondrial DNA were seen in older mice, suggesting that mitochondrial DNA repair mechanisms may be involved in various neurodegenerative disorders in an age-dependent manner. This UNG1 antibody will not cross-react with UNG2.

7374

P13051

NP_003353

Human, Mouse

3863

Unconjugated

Primary Antibodies

Independent Antibody Validation in Cell lines (Figure 2) shows similar UNG1 expression profile in human cell lines detected by two independent anti-UNG1 antibodies that recognize different epitopes, 3863 against C-terminus domain and 3865 against central domain. UNG1 proteins are detected in all tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines3863 3865

Neuroscience, Infectious Disease

UNG1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1285 - C2C12 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat (85%) .

UNG1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

UNG1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human UNG1 has 2 isoforms, including isoform 1 (304aa, 34kD) and isoform 2 (313aa, 35kD) . Mouse UNG1 has 2 isoforms, including isoform 1 (295aa, 33kD) and isoform 2 (306aa, 34kD) . Rat UNG1 has one isoform (303aa, 34kD) . 3863 can detect human, mouse and rat.

UNG

Cat. No. 1301 - Human Heart Tissue Lysate

Cat. No. 10-501 - Human Heart Tissue Slide

Uracil-DNA glycosylase

Homo sapiens

Krokan et al. Prog. Nucleic Acid Res. Mol. Biol. 2001; 68:365-86.

Fromm and Verdine. Adv. Protein Chem. 2004; 69:1-41.

Kachhap and Singh. Mol. Cancer 2004; 3:32.

Imam et al. Neurobiol. Aging 2006; 27:1129-36.

UNG1 Antibody: DGU, UDG, UNG1, UNG2, HIGM4, HIGM5, UNG15, DGU, Uracil-DNA glycosylase

ELISA, WB, IHC-P, IF

6224979

Liquid