UPF1 Antilichaam

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD) . When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants.

5976

Q92900

Human, Mouse

A synthetic peptide corresponding to a sequence within amino acids 270-370 of human UPF1 (NP_002902.2) .

Unconjugated

Primary Antibodies

Apoptosis, Cell Cycle

Affinity purification

293T

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 130kDa

IgG

UPF1

SH-SY5Y

K-562

HL-60

Mouse liver

UPF1 regulator of nonsense transcripts homolog (yeast)

Homo sapiens

UPF1, FLJ43809, FLJ46894, HUPF1, KIAA0221, NORF1, RENT1, pNORF1, smg-2

WB, IF

Liquid